Table 5. Estimates of genotype relative risks based on case-pseudocontrol data using the GenAssoc package.
|
Marker |
Genotype |
GRR |
Z score |
p value |
95% CI |
Global Wald test p value |
| rs2421853 |
C/C |
1 |
- |
- |
- |
9.00E-04 |
| C/T |
1.678 |
3.19 |
0.0014 |
1.222-2.308 |
||
| T/T |
2.738 |
2.76 |
0.0057 |
1.340-5.593 |
||
| rs235858 |
C/C |
1 |
- |
- |
- |
2.00E-06 |
| C/T |
2.083 |
3.13 |
0.0017 |
1.316-3.298 |
||
| T/T | 3.931 | 5.01 | 5.50E-07 | 2.301-6.717 | ||
The table shows the effect sizes of the genotypes in terms of genotype relative risk (GRR) and the corresponding 95% confidence intervals (CI). For each genotype, the Z score is the statistic testing the deviation of the GRR from 1 and the significance level as the p value. For each SNP, the significance of the global Wald test is indicated in the last column. Robust variance estimates were used to account for correlation between contributions from nuclear families with two or more siblings.