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. 2007 Apr 4;13:566–577.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of H₂O₂ treatment in retinal pigment epithelium from αA-crystallin(-/-) and wild type mice on caspase-3 activation and mitochondrial membrane permeability transition. A: Caspase-3 activation was measured by staining with FITC-VAD-FMK. αA(-/-) retinal pigment epithelium (RPE) showed an increase in caspase-3 activation compared to wild type under H2O2 treatment. B: αA(-/-) RPE also exhibited an increase in mitochondrial permeability transition compared to wild type RPE under H₂O₂ treatment.