Table 2. Estimated hazard of mortality due to carrying a BRCA mutation in the absence of melanoma and cancer of the breast, ovary, pancreas, and prostate1.
Age | Female | Male | ||||
Non-carriers | Carriers | Hazard Ratio | Non-carrier | Carrier | Hazard Ratio | |
<50 | .038 (.034, .042) | .056 (.018, .102) | 1.46 (0.50, 2.82) | .066 (.061, .071) | .079 (.026, .142) | 1.19 (0.38, 2.20) |
51–60 | .038 (.033, .044) | .047 (.000, .129) | 1.26 (0.00, 3.42) | .092 (.084, .099) | .073 (.023, .152) | 0.80 (0.25, 1.68) |
61–70 | .091 (.082, .101) | .118 (.021, .284) | 1.29 (0.22, 3.07) | .179 (.168, .192) | .312 (.166, .451) | 1.74 (0.89, 2.55) |
71–80 | .242 (.225, .260) | .630 (.334, .857) | 2.60 (1.39, 3.64) | .374 (.353, .396) | .612 (.320, .825) | 1.64 (0.85, 2.25) |
81–90 | .593 (.556, .629) | .634 (.143, .972) | 1.07 (0.25, 1.65) | .704 (.668, .741) | .844 (.418, .980) | 1.20 (0.58, 1.42) |
91–100 | .880 (.816, .936) | .853 (.030, .975) | 0.97 (0.03, 1.08) | .947 (.874, .997) | .820 (.000, .100) | 0.87 (0.00, 1.08) |
Follow-up time and deaths were censored at first report of melanoma or cancer of the breast, ovary, pancreas, or prostate.