Table 2. Data of healthy subjects and cystic fibrosis (CF) patients.
| Controls | CF patients | p-value | |
| Age (years) | 5.9±2.1 | 6.7±1.4 | |
| Sex (M/F) | 5/5 | 9/13 | |
| MTHFR 677 C>T polymorphism | NA | w/w 42 % | |
| NA | w/m 35 % | ||
| NA | m/m 23 % | ||
| Plasma folate (ng/ml) | 5.88 (4.07–6.74) | 6.62 (4.99–8.16) | 0.174 |
| RBCs folate (ng/ml) | 49.4 (27.03–82.8) | 451.5 (339.0–708.0) | 0.004 |
| Plasma vitamin B12 (pg/ml) | 896 (660–1055) | 1157 (871–1448) | 0.159 |
| Plasma homocysteine (µmol/l) | 6.90 (6.70–7.90) | 7.50 (6.85–8.50) | 0.424 |
| RBCs MDA (µmol/g Hb) | 12.65 (11.45–13.85) | 13.70 (11.90–16.30) | 0.232 |
RBCs: red blood cells; N: rare mutation; NA: not applicable; MTHFR: methylenetetrahydrofolate reductase; w/w: wild; w/m: heterozygote; m/m: mutant; MDA: malondialdehyde. Data are summarized as mean±sd for age, frequency for sex and genotype, medians and interquantile ranges for folate, vitamin B12, homocysteine and MDA.