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. 2008 Jul 7;26(30):4958–4965. doi: 10.1200/JCO.2007.14.6571

Table 1.

Risks of Lymphoproliferative Malignancies Among First-Degree Relatives of Patients With Chronic Lymphocytic Leukemia, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, and Multiple Myeloma

Patient's Condition Reference First-Degree Relative's Risk
Chronic Lymphocytic Leukemia
Hodgkin's Lymphoma
Non-Hodgkin's Lymphoma
Multiple Myeloma
OR 95% CI OR 95% CI OR 95% CI OR 95% CI
Chronic lymphocytic leukemia Goldin et al5 7.5 3.6 to 15.6 2.4 1.1 to 5.1 1.5 1.0 to 2.2 1.1 0.5 to 2.4
Hodgkin's lymphoma Goldin et al21 2.1 1.2 to 3.8 3.1 1.8 to 5.3 1.3 0.9 to 1.8 1.0 0.6 to 1.8
Non-Hodgkin's lymphoma Goldin et al27 1.3 0.9 to 1.9 1.4 1.0 to 2.0 1.7 1.4 to 2.2 1.1 0.8 to 1.5
Multiple myeloma Landgren et al50 0.9 0.4 to 1.9 0.7 0.4 to 1.5 1.2 0.8 to 1.7 1.7 1.0 to 2.7

NOTE. Italic font indicates not significant. Bold font indicates increased risk P < .05. Table constructed using odds ratios and 95% CIs for the risk of lymphoproliferative malignancy in relatives of patients diagnosed in Sweden and Denmark with chronic lymphocytic leukemia, Hodgkin's lymphoma, non-Hodgkin's lymphoma, and multiple myeloma as reported in the respective publications.