Table 3.
Comparison of Patients With Lymphoma With and Without a Family History of Any Lymphoma
| Variable | CLL
|
HL
|
NHL
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Family History
|
With Family History*
|
P | No Family History
|
With Family History*
|
P | No Family History
|
With Family History*
|
P | |||||||
| No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | ||||
| No. of patients | 7,664 | 85 | 7,381 | 95 | 25,595 | 206 | |||||||||
| Sex | .645 | .015 | .944 | ||||||||||||
| Male | 5,080 | 66.3 | 54 | 63.5 | 4,446 | 60.2 | 69 | 72.6 | 14,869 | 58.1 | 119 | 57.8 | |||
| Female | 2,584 | 33.7 | 31 | 36.5 | 2,935 | 39.8 | 26 | 27.4 | 10,726 | 41.9 | 87 | 42.2 | |||
| Age group† | .913 | < .001 | < .001 | ||||||||||||
| Younger patients | 3,722 | 48.6 | 42 | 49.4 | 4,348 | 58.9 | 71 | 74.7 | 12,422 | 48.5 | 128 | 62.1 | |||
| Older patients | 3,942 | 51.4 | 43 | 50.6 | 3,033 | 41.1 | 24 | 25.3 | 13,173 | 51.5 | 78 | 37.9 | |||
| Diagnosis year | .996 | .051 | .631 | ||||||||||||
| 1958-1967 | 548 | 7.2 | 6 | 7.1 | 847 | 11.5 | 5 | 5.3 | 1,268 | 5.0 | 9 | 4.4 | |||
| 1968-1977 | 1,118 | 14.6 | 12 | 14.1 | 1,873 | 25.4 | 32 | 33.7 | 3,496 | 13.7 | 26 | 12.6 | |||
| 1978-1987 | 2,420 | 31.6 | 28 | 32.9 | 2,147 | 29.1 | 32 | 33.7 | 7,242 | 28.3 | 67 | 32.5 | |||
| 1988-1998 | 3,578 | 46.7 | 39 | 45.9 | 2,514 | 34.1 | 26 | 27.4 | 13,589 | 53.1 | 104 | 50.5 | |||
| Registry | .020 | .008 | < .001 | ||||||||||||
| Sweden | 5,853 | 76.4 | 74 | 87.1 | 4,971 | 67.3 | 76 | 80.0 | 19,472 | 76.1 | 179 | 86.9 | |||
| Denmark | 1,811 | 23.6 | 11 | 12.9 | 2,410 | 32.7 | 19 | 20.0 | 6,123 | 23.9 | 27 | 13.1 | |||
| Histopathologic | |||||||||||||||
| NHL subtype | .308 | ||||||||||||||
| High-grade B cell | NA | NA | NA | NA | NA | NA | NA | NA | 2,284 | 13 | |||||
| Low-grade B cell | NA | NA | NA | NA | NA | NA | NA | NA | 4,331 | 28 | |||||
| T-cell/anaplastic | NA | NA | NA | NA | NA | NA | NA | NA | 610 | 5 | |||||
| Missing | NA | NA | NA | NA | NA | NA | NA | NA | 18,510 | 160 | |||||
Abbreviations: CLL, chronic lymphocytic leukemia; HL, Hodgkin's lymphoma; NHL, non-Hodgkin's lymphoma; NA, not available.
*
A known diagnosis of CLL, HL, and/or NHL in at least one first-degree relative before the diagnosis date of the patient.
†
Age cut-offs for CLL, HL, and NHL were 67, 45, and 62 years, respectively.