Table 4.
HR Estimates and 95% CIs for 5- and 10-Year Mortality
| Variable | Mortality
|
|||
|---|---|---|---|---|
| 5-Year | 10-Year | |||
| HR* | 95% CI | HR* | 95% CI | |
| CLL | ||||
| Family history of any lymphoma† | 1.28 | 0.95 to 1.72 | 1.24 | 0.93 to 1.67 |
| Male sex‡ | 1.42§ | 1.32 to 1.52 | 1.41§ | 1.33 to 1.52 |
| Age at diagnosis, ≥ 67 years¶ | 1.47§ | 1.43 to 1.51 | 2.13§ | 2.00 to 2.26 |
| Year of diagnosis, per decade‖ | 0.74§ | 0.70 to 0.76 | 0.81§ | 0.78 to 0.84 |
| HL | ||||
| Family history of any lymphoma† | 0.78 | 0.49 to 1.25 | 0.78 | 0.51 to 1.19 |
| Male sex‡ | 1.22§ | 1.12 to 1.33 | 1.22§ | 1.14 to 1.32 |
| Age at diagnosis, per quintile¶ | 2.07§ | 1.99 to 2.15 | 2.03§ | 1.96 to 2.10 |
| Year of diagnosis, per decade‖ | 0.59§ | 0.54 to 0.64 | 0.77§ | 0.74 to 0.80 |
| HL, < age 45 years | ||||
| Family history of any lymphoma† | 0.65 | 0.31 to 1.36 | 0.74 | 0.41 to 1.35 |
| Male sex‡ | 1.33** | 1.13 to 1.56 | 1.32§ | 1.14 to 1.52 |
| Age at diagnosis, ≥ 27 years¶ | 1.82§ | 1.55 to 2.14 | 1.66§ | 1.44 to 1.90 |
| Year of diagnosis, per decade‖ | 0.59§ | 0.54 to 0.64 | 0.61§ | 0.57 to 0.66 |
| HL, ≥ age 45 years | ||||
| Family history of any lymphoma† | 1.07 | 0.59 to 1.94 | 0.93 | 0.51 to 1.69 |
| Male sex‡ | 1.21** | 1.10 to 1.34 | 1.23§ | 1.12 to 1.35 |
| Age at diagnosis, ≥ 61 years¶ | 2.48§ | 2.24 to 2.75 | 2.50§ | 2.27 to 2.76 |
| Year of diagnosis, per decade‖ | 0.80§ | 0.76 to 0.84 | 0.82§ | 0.78 to 0.86 |
| NHL | ||||
| Family history of any lymphoma† | 0.91 | 0.74- to 1.12 | 0.97 | 0.80 to 1.16 |
| Male sex‡ | 1.20§ | 1.16 to 1.24 | 1.32§ | 1.23 to 1.41 |
| Age at diagnosis, per quintile¶ | 1.42§ | 1.40 to 1.44 | 1.47§ | 1.45 to 1.49 |
| Year of diagnosis, per decade‖ | 0.75§ | 0.73 to 0.78 | 0.83§ | 0.82 to 0.85 |
| High-grade B-cell lymphoma | ||||
| Family history of any lymphoma† | 0.80 | 0.33 to 1.93 | 1.02 | 0.49 to 2.16 |
| Male sex‡ | 1.24** | 1.10 to 1.39 | 1.20§ | 1.08 to 1.37 |
| Age at diagnosis, per quintile¶ | 1.39§ | 1.33 to 1.45 | 1.42§ | 1.36 to 1.48 |
| Year of diagnosis, per decade‖ | 0.84** | 0.74 to 0.95 | 0.84§ | 0.74 to 0.94 |
| Low-grade B-cell lymphoma | ||||
| Family history of any lymphoma† | 1.04 | 0.56 to 1.93 | 1.14 | 0.66 to 1.98 |
| Male sex‡ | 1.36§ | 1.23 to 1.50 | 1.32§ | 1.22 to 1.45 |
| Age at diagnosis, per quintile¶ | 1.59§ | 1.52 to 1.66 | 1.56§ | 1.51 to 1.62 |
| Year of diagnosis, per decade‖ | 0.80§ | 0.74 to 0.92 | 0.79§ | 0.72 to 0.87 |
| T-cell/anaplastic lymphoma | ||||
| Family history of any lymphoma† | 2.69 | 0.85 to 8.47 | 1.86 | 0.59 to 5.83 |
| Male sex‡ | 1.66** | 1.24 to 2.23 | 1.59§ | 1.22 to 2.08 |
| Age at diagnosis, per quintile¶ | 1.44§ | 1.31 to 1.59 | 1.45§ | 1.33 to 1.59 |
| Year of diagnosis, per decade‖ | 2.47§ | 1.66 to 3.68 | 1.88§ | 1.37 to 2.58 |
NOTE. All models are multivariable Cox regression models which include family history of any lymphoma, age at diagnosis, year of diagnosis, and country of residence (estimates not shown). Bold font indicates the risk of dying for patients with a family history of lymphoma compared with patients without a family history of lymphoma.
Abbreviations: HR, hazard ratio; CLL, chronic lymphocytic leukemia; HL, Hodgkin's lymphoma; NHL, non-Hodgkin's lymphoma.
Adjusted for registry and mutually adjusted for the other variables in Table 2.
Family history of any lymphoma: Baseline = no family history of any lymphoma. Family history of any lymphoma is defined as a known diagnosis of CLL, HL or NHL in at least one first-degree relative before the diagnosis date of the patient.
Male sex: baseline = female.
P < .001.
Age at diagnosis: baseline for CLL = patients age < 67 years; baseline for HL = patients age < 23 years (categories included: < 23, 23-31, 32-44, 45-60, 61+ years); baseline for HL = < 45 years = < 27 years; baseline for HL ≥ 45 years = < 61 years; baseline for NHL, high-grade B-cell lymphoma, low-grade B-cell lymphoma, and T-cell/anaplastic lymphoma = < 46 years (categories included: < 46, 46 to 56, 57 to 65, 66 to 73, 74+ years).
Year of diagnosis: baseline = 1958 to 1967 (categories included: 1958 to 1967, 1968 to 1977, 1978 to 1987, 1988 to 1998).
P < .05.