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High-grade serous carcinogenic sequence. The spectrum of fallopian tube (FT) epithelial transformation ranges from normal epithelium, through p53 signature, an intraepithelial, and eventually, an invasive carcinoma. Exfoliation into the peritoneal cavity is an early event. This model suggests that all types of pelvic serous tumors are the same entity, the majority of which originate from the FT fimbria. TIC, tubal intraepithelial carcinoma.
