Fig 2.

Adoptive cell therapy after lymphodepletion. (A) Telomere length of infused tumor-infiltrating lymphocytes (TIL) correlates with clinical response. Flow-fluorescent in situ hybridization analysis was used to quantify the mean telomere length of infused TIL for patients on all three protocols. (B) Lymphodepleting conditioning markedly increases the levels of circulating homeostatic cytokines, interleukin (IL)-7 and IL-15. Serum samples were evaluated before therapy (Pre) and immediately before TIL administration (day 0). NMA, nonmyeloablative; TBI, total-body irradiation.