Table 3.

Overall and Disease-Free Survival for All Patients Stratified by Tumor Size

Survival Outcome	Survival Analyses
	Overall					Disease-Free
	Adjuvant Chemotherapy	Control	P	HR	90% CI	Adjuvant Chemotherapy	Control	P	HR	90% CI
Intent-to-treat analysis of all randomly assigned patients
No. of patients	173	171				173	171
Recurrence or death			.125	0.83	0.64 to 1.08			.065	0.80	0.62 to 1.02
No.	74	81				81	92
%	43	47				47	54
1-year
%	94	94	.50			85	81	.079
90% CI, %	91 to 98	91 to 97				80 to 90	75 to 87
2-year
%	90	84	.053			75	68	.048
90% CI, %	86 to 95	79 to 90				68 to 81	62 to 76
3-year
%	80	73	.020			67	58	.0048
90% CI, %	74 to 86	65 to 79				60 to 74	51 to 66
4-year
%	70	62	.045			60	54	.060
90% CI, %	63 to 77	55 to 70				53 to 68	47 to 62
5-year
%	60	58	.190			52	48	.117
90% CI, %	52 to 68	51 to 66				45 to 61	41 to 57
6-year
%	55	53	.353			51	46	.094
90% CI, %	48 to 64	45 to 62				43 to 59	38 to 54
Tumor size ≥ 4 cm in diameter
No. of patients	99	97				99	97
Recurrence or death
No.	37	53	.042	0.69	0.48 to 0.99	42	53	.035	0.69	0.49 to 0.97
%	38	55				42	55
1-year
%	94	92	.284			82	76	.182
90% CI, %	90 to 98	87 to 97				74 to 90	68 to 85
2-year
%	90	81	.047			71	67	.259
90% CI, %	85 to 95	75 to 88				63 to 81	58 to 77
3-year
%	78	71	.126			66	56	.085
90% CI, %	71 to 85	64 to 79				57 to 76	47 to 67
4-year
%	71	64	.141			63	54	.105
90% CI, %	60 to 79	56 to 73				53 to 73	44 to 65
5-year
%	64	61	.355			59	51	.141
90% CI, %	56 to 73	53 to 70				49 to 70	41 to 62
6-year
%	60	54	.197			55	47	.137
90% CI, %	52 to 70	45 to 64				46 to 67	37 to 59
Tumor size < 4 cm in diameter
No. of patients	63	71				63	71
Recurrence or death
No.	34	33	.32	1.12	0.75 to 1.67	36	38	.49	1.01	0.69 to 1.48
%	54	46				57	54
1-year
%	94	97	.165			89	86	.308
90% CI, %	89 to 99	94 to 100				81 to 97	78 to 94
2-year
%	90	87	.280			79	70	.119
90% CI, %	84 to 97	91 to 94				70 to 90	60 to 82
3-year
%	81	73	.141			66	60	.234
90% CI, %	73 to 89	64 to 82				55 to 79	50 to 73
4-year
%	67	62	.272			56	55	.477
90% CI, %	58 to 78	53 to 73				45 to 70	45 to 69
5-year
%	52	54	.392			40	46	.278
90% CI, %	42 to 64	45 to 65				29 to 55	35 to 59
6-year
%	45	52	.221			40	44	.353
90% CI, %	35 to 58	43 to 63				29 to 55	33 to 58

Abbreviation: HR, hazard ratio.