Table 3.
Overall and Disease-Free Survival for All Patients Stratified by Tumor Size
Survival Outcome | Survival Analyses
|
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---|---|---|---|---|---|---|---|---|---|---|
Overall
|
Disease-Free
|
|||||||||
Adjuvant Chemotherapy | Control | P | HR | 90% CI | Adjuvant Chemotherapy | Control | P | HR | 90% CI | |
Intent-to-treat analysis of all randomly assigned patients | ||||||||||
No. of patients | 173 | 171 | 173 | 171 | ||||||
Recurrence or death | .125 | 0.83 | 0.64 to 1.08 | .065 | 0.80 | 0.62 to 1.02 | ||||
No. | 74 | 81 | 81 | 92 | ||||||
% | 43 | 47 | 47 | 54 | ||||||
1-year | ||||||||||
% | 94 | 94 | .50 | 85 | 81 | .079 | ||||
90% CI, % | 91 to 98 | 91 to 97 | 80 to 90 | 75 to 87 | ||||||
2-year | ||||||||||
% | 90 | 84 | .053 | 75 | 68 | .048 | ||||
90% CI, % | 86 to 95 | 79 to 90 | 68 to 81 | 62 to 76 | ||||||
3-year | ||||||||||
% | 80 | 73 | .020 | 67 | 58 | .0048 | ||||
90% CI, % | 74 to 86 | 65 to 79 | 60 to 74 | 51 to 66 | ||||||
4-year | ||||||||||
% | 70 | 62 | .045 | 60 | 54 | .060 | ||||
90% CI, % | 63 to 77 | 55 to 70 | 53 to 68 | 47 to 62 | ||||||
5-year | ||||||||||
% | 60 | 58 | .190 | 52 | 48 | .117 | ||||
90% CI, % | 52 to 68 | 51 to 66 | 45 to 61 | 41 to 57 | ||||||
6-year | ||||||||||
% | 55 | 53 | .353 | 51 | 46 | .094 | ||||
90% CI, % | 48 to 64 | 45 to 62 | 43 to 59 | 38 to 54 | ||||||
Tumor size ≥ 4 cm in diameter | ||||||||||
No. of patients | 99 | 97 | 99 | 97 | ||||||
Recurrence or death | ||||||||||
No. | 37 | 53 | .042 | 0.69 | 0.48 to 0.99 | 42 | 53 | .035 | 0.69 | 0.49 to 0.97 |
% | 38 | 55 | 42 | 55 | ||||||
1-year | ||||||||||
% | 94 | 92 | .284 | 82 | 76 | .182 | ||||
90% CI, % | 90 to 98 | 87 to 97 | 74 to 90 | 68 to 85 | ||||||
2-year | ||||||||||
% | 90 | 81 | .047 | 71 | 67 | .259 | ||||
90% CI, % | 85 to 95 | 75 to 88 | 63 to 81 | 58 to 77 | ||||||
3-year | ||||||||||
% | 78 | 71 | .126 | 66 | 56 | .085 | ||||
90% CI, % | 71 to 85 | 64 to 79 | 57 to 76 | 47 to 67 | ||||||
4-year | ||||||||||
% | 71 | 64 | .141 | 63 | 54 | .105 | ||||
90% CI, % | 60 to 79 | 56 to 73 | 53 to 73 | 44 to 65 | ||||||
5-year | ||||||||||
% | 64 | 61 | .355 | 59 | 51 | .141 | ||||
90% CI, % | 56 to 73 | 53 to 70 | 49 to 70 | 41 to 62 | ||||||
6-year | ||||||||||
% | 60 | 54 | .197 | 55 | 47 | .137 | ||||
90% CI, % | 52 to 70 | 45 to 64 | 46 to 67 | 37 to 59 | ||||||
Tumor size < 4 cm in diameter | ||||||||||
No. of patients | 63 | 71 | 63 | 71 | ||||||
Recurrence or death | ||||||||||
No. | 34 | 33 | .32 | 1.12 | 0.75 to 1.67 | 36 | 38 | .49 | 1.01 | 0.69 to 1.48 |
% | 54 | 46 | 57 | 54 | ||||||
1-year | ||||||||||
% | 94 | 97 | .165 | 89 | 86 | .308 | ||||
90% CI, % | 89 to 99 | 94 to 100 | 81 to 97 | 78 to 94 | ||||||
2-year | ||||||||||
% | 90 | 87 | .280 | 79 | 70 | .119 | ||||
90% CI, % | 84 to 97 | 91 to 94 | 70 to 90 | 60 to 82 | ||||||
3-year | ||||||||||
% | 81 | 73 | .141 | 66 | 60 | .234 | ||||
90% CI, % | 73 to 89 | 64 to 82 | 55 to 79 | 50 to 73 | ||||||
4-year | ||||||||||
% | 67 | 62 | .272 | 56 | 55 | .477 | ||||
90% CI, % | 58 to 78 | 53 to 73 | 45 to 70 | 45 to 69 | ||||||
5-year | ||||||||||
% | 52 | 54 | .392 | 40 | 46 | .278 | ||||
90% CI, % | 42 to 64 | 45 to 65 | 29 to 55 | 35 to 59 | ||||||
6-year | ||||||||||
% | 45 | 52 | .221 | 40 | 44 | .353 | ||||
90% CI, % | 35 to 58 | 43 to 63 | 29 to 55 | 33 to 58 |
Abbreviation: HR, hazard ratio.