Table A1.
Interim Efficacy Analyses
| Analysis Group | No. of Deaths per Treatment Group
|
P | P Threshold for Statistical Significance† | |||
|---|---|---|---|---|---|---|
| Observation | Chemotherapy | Total*
|
||||
| No. | % | |||||
| 1 | 22 | 13 | 35 | 23 | .115 | |
| 2 | 26 | 19 | 45 | 29 | .127 | |
| 3 | 42 | 24 | 66 | 43 | .008 | < .0028 |
| 4 | 49 | 30 | 79 | 51 | .005 | < .0094 |
*
Percentage of the required number of deaths for the study to be fully mature.
†
Calculated according to the O’Brien-Fleming decision rule and computed with S+ SeqTrial (S+ SeqTrial User's Manual 2000, Data Analysis Products Division; MathSoft, Seattle, WA).