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. Author manuscript; available in PMC: 2010 Feb 4.
Published in final edited form as: J Am Chem Soc. 2009 Feb 4;131(4):1550–1556. doi: 10.1021/ja8082818

Figure 6.

Figure 6

Positions of residues (red) that have a significant (de)stabilization to the TS during catalysis for any of the three systems. Metal binding residues and H162 are shown in blue. Hydrogens have been omitted for clarity.