Table I.
miRNAs that are significantly changed in H69 cells following IFN-γ stimulation
| Log2 (Hy5/Hy3) Ratios |
|||
|---|---|---|---|
| miRNAs | Control | IFN-γ | p |
| hsa-let-7e | 1.226 ± 0.031 | 0.744 ± 0.215 | 0.025 |
| hsa-let-7f | 0.998 ± 0.078 | 0.508 ± 0.178 | 0.021 |
| hsa-let-7i | 0.963 ± 0.049 | 0.531 ± 0.245 | 0.049 |
| hsa-miR-1 | 0.324 ± 0.291 | -0.489 ± 0.128 | 0.037 |
| hsa-miR-100 | 1.420 ± 0.177 | 0.811 ± 0.225 | 0.041 |
| hsa-miR-106b | 1.391 ± 0.071 | 0.887 ± 0.218 | 0.028 |
| hsa-miR-107 | 0.927 ± 0.084 | 0.476 ± 0.225 | 0.044 |
| hsa-miR-125a-5p | 1.109 ± 0.083 | 0.683 ± 0.223 | 0.049 |
| hsa-miR-126 | 0.362 ± 0.057 | -0.318 ± 0.351 | 0.037 |
| hsa-miR-129* | 0.758 ± 0.114 | 0.178 ± 0.026 | 0.007 |
| hsa-miR-138 | 1.139 ± 0.096 | 0.665 ± 0.166 | 0.025 |
| hsa-miR-148b | 0.509 ± 0.063 | -0.035 ± 0.308 | 0.049 |
| hsa-miR-15a | 1.204 ± 0.057 | 0.813 ± 0.145 | 0.021 |
| hsa-miR-15b | 1.336 ± 0.112 | 0.885 ± 0.181 | 0.038 |
| hsa-miR-16 | 1.422 ± 0.064 | 1.009 ± 0.196 | 0.036 |
| hsa-miR-182 | 0.792 ± 0.112 | 0.153 ± 0.218 | 0.021 |
| hsa-miR-183 | 1.297 ± 0.221 | 0.149 ± 0.496 | 0.034 |
| hsa-miR-185 | 1.091 ± 0.126 | 0.517 ± 0.103 | 0.013 |
| hsa-miR-186 | -0.708 ± 0.030 | -1.354 ± 0.376 | 0.048 |
| hsa-miR-193b | 1.062 ± 0.088 | 0.550 ± 0.248 | 0.039 |
| hsa-miR-195 | 0.965 ± 0.087 | 0.454 ± 0.261 | 0.044 |
| hsa-miR-196a* | 0.518 ± 0.072 | -0.317 ± 0.171 | 0.004 |
| hsa-miR-197 | 0.520 ± 0.063 | 0.068 ± 0.184 | 0.025 |
| hsa-miR-19a | 1.266 ± 0.054 | 0.827 ± 0.213 | 0.035 |
| hsa-miR-19b | 1.280 ± 0.163 | 0.757 ± 0.154 | 0.037 |
| hsa-miR-20a | 1.448 ± 0.025 | 0.995 ± 0.244 | 0.040 |
| hsa-miR-214 | 0.269 ± 0.100 | -0.167 ± 0.094 | 0.016 |
| hsa-miR-22 | 1.278 ± 0.122 | 0.803 ± 0.155 | 0.030 |
| hsa-miR-23b | 1.204 ± 0.009 | 0.671 ± 0.228 | 0.021 |
| hsa-miR-24 | 1.093 ± 0.058 | 0.622 ± 0.146 | 0.013 |
| hsa-miR-24-1* | 0.799 ± 0.064 | 0.085 ± 0.227 | 0.012 |
| hsa-miR-28-5p | 1.186 ± 0.098 | 0.699 ± 0.243 | 0.046 |
| hsa-miR-29b-1* | -0.664 ± 0.082 | -0.155 ± 0.205 | 0.026 |
| hsa-miR-300 | 0.811 ± 0.015 | 0.243 ± 0.133 | 0.004 |
| hsa-miR-302d* | 1.011 ± 0.082 | 0.456 ± 0.072 | 0.004 |
| hsa-miR-30b | 1.258 ± 0.067 | 0.810 ± 0.206 | 0.033 |
| hsa-miR-30b* | 0.887 ± 0.065 | 0.371 ± 0.198 | 0.021 |
| hsa-miR-30c-2* | 1.106 ± 0.081 | 0.554 ± 0.135 | 0.010 |
| hsa-miR-30d | 0.801 ± 0.124 | 0.296 ± 0.162 | 0.028 |
| hsa-miR-423-3p | 1.131 ± 0.033 | 0.675 ± 0.253 | 0.044 |
| hsa-miR-452 | 0.389 ± 0.057 | -0.191 ± 0.302 | 0.039 |
| hsa-miR-491-3p | 0.798 ± 0.088 | 0.286 ± 0.115 | 0.011 |
| hsa-miR-513 | 0.746 ± 0.134 | -0.262 ± 0.463 | 0.032 |
| hsa-miR-518c* | 0.799 ± 0.132 | 0.219 ± 0.090 | 0.013 |
| hsa-miR-549 | 1.106 ± 0.141 | 0.471 ± 0.022 | 0.009 |
| hsa-miR-550 | 1.042 ± 0.142 | 0.465 ± 0.232 | 0.038 |
| hsa-miR-551b | 1.323 ± 0.123 | 0.755 ± 0.124 | 0.015 |
| hsa-miR-574-5p | 0.777 ± 0.131 | 0.138 ± 0.027 | 0.007 |
| hsa-miR-576-3p | 0.980 ± 0.118 | 0.315 ± 0.172 | 0.013 |
| hsa-miR-583 | 0.557 ± 0.111 | -0.079 ± 0.036 | 0.005 |
| hsa-miR-600 | 0.439 ± 0.221 | -0.768 ± 0.484 | 0.028 |
| hsa-miR-620 | 1.227 ± 0.145 | 0.634 ± 0.008 | 0.012 |
| hsa-miR-620 | 1.087 ± 0.172 | 0.462 ± 0.001 | 0.016 |
| hsa-miR-634 | 0.641 ± 0.087 | 0.197 ± 0.179 | 0.030 |
| hsa-miR-642 | 0.468 ± 0.131 | -0.138 ± 0.081 | 0.011 |
| hsa-miR-658 | 1.044 ± 0.118 | 0.460 ± 0.055 | 0.008 |
| hsa-miR-665 | 1.092 ± 0.098 | 0.637 ± 0.035 | 0.009 |
| hsa-miR-765 | 0.895 ± 0.173 | 0.333 ± 0.001 | 0.022 |
| hsa-miR-886-5p | 1.693 ± 0.181 | 0.639 ± 0.533 | 0.043 |
| hsa-miR-921 | 1.251 ± 0.060 | 0.814 ± 0.126 | 0.012 |
| hsa-miR-93 | 1.125 ± 0.072 | 0.594 ± 0.255 | 0.035 |
| hsa-miR-939 | 0.947 ± 0.082 | 0.415 ± 0.061 | 0.005 |
| hsa-miR-96 | 0.844 ± 0.108 | 0.252 ± 0.203 | 0.021 |
| miRPlus_17869 | 1.207 ± 0.057 | 0.720 ± 0.232 | 0.033 |
| miRPlus_42487 | 0.973 ± 0.108 | 0.465 ± 0.214 | 0.035 |
| miRPlus_42530 | 0.246 ± 0.078 | -0.200 ± 0.199 | 0.034 |
| hsa-miR-30e | 1.247 ± 0.073 | 0.758 ± 0.234 | 0.036 |
| hsa-miR-30e* | 0.164 ± 0.097 | -0.491 ± 0.313 | 0.036 |
| hsa-miR-31* | 0.996 ± 0.135 | 0.473 ± 0.180 | 0.032 |
| hsa-miR-32* | 0.922 ± 0.024 | 0.415 ± 0.015 | 0.000 |
| hsa-miR-339-5p | 0.882 ± 0.098 | 0.428 ± 0.140 | 0.022 |
| hsa-miR-340 | 0.964 ± 0.115 | 0.414 ± 0.222 | 0.032 |
| hsa-miR-342-3p | 0.785 ± 0.060 | 0.109 ± 0.170 | 0.007 |
| hsa-miR-34a | 1.179 ± 0.112 | 0.769 ± 0.110 | 0.027 |
| hsa-miR-34b | 1.344 ± 0.121 | 0.676 ± 0.020 | 0.005 |
| hsa-miR-374a | 1.350 ± 0.072 | 0.831 ± 0.206 | 0.023 |
| hsa-miR-374b* | -0.152 ± 0.072 | -1.138 ± 0.123 | 0.001 |
Data represent the log2 (Hy5/Hy3) ratios from nonstimulated and IFN-γ-stimulated (10 ng/ml) samples by using the miRCURY LNA Array (version 10.0). A total of 76 miRNAs were down-regulated and miR-29b-1* was up-regulated in H69 cells following IFN-γ stimulation for 8 h (p < 0.05).