Figure 4. Effect of BCTC on the frequency response to repeated colorectal distension and spontaneous activity of pelvic afferent neurons.
Effect of BCTC (0.25, 0.5, 1, 2 and 5 mg kg−1i.v.) or its vehicle (25% hydroxypropyl-β-cyclodextrin) on the frequency response to repeated colorectal distension (60 mmHg, 20 s, 4 min interval) (A–C) and the spontaneous activity (D–F) of pelvic afferent neurons in controls and in rats with TNBS-induced colitis. Results are shown for all neurons (A and D), for C-fibres only (B and E) and for Aδ-fibres only (C and F). *P < 0.05, significantly different from controls; #P < 0.05, significantly different from vehicle treatment, repeated measures two-way ANOVA with post hoc Student–Newman–Keuls analysis.