Table 3.
Haemodynamic variables during the PET measurements
| Rest | ADO | [11C]TMSX | ||||
|---|---|---|---|---|---|---|
| ET | UT | ET | UT | ET | UT | |
| HR (beats min−1) | 47 ± 7*** | 59 ± 8 | 80 ± 9*** | 103 ± 11† | 47 ± 6*** | 61 ± 8 |
| BPs (mmHg) | 123 ± 7* | 115 ± 11 | 127 ± 8* | 117 ± 10 | 126 ± 12* | 115 ± 11 |
| BPd (mmHg) | 64 ± 5 | 68 ± 7 | 66 ± 5 | 67 ± 8 | 70 ± 9 | 69 ± 8 |
| MAP (mmHg) | 84 ± 4 | 84 ± 8 | 86 ± 5 | 84 ± 9 | 89 ± 9 | 84 ± 8 |
| LV work (mmHg l min−1 g−1) | 1.1 ± 0.2*** | 2.0 ± 0.4 | 2.0 ± 0.2*** | 3.5 ± 0.6† | 1.2 ± 0.2*** | 2.1 ± 0.5 |
| Total LV work (mmHg l min−1) | 433 ± 79 | 448 ± 82 | 753 ± 89† | 765 ± 93† | 474 ± 103 | 456 ± 85 |
| MBF (ml min−1 g−1) | 0.56 ± 0.13*** | 0.69 ± 0.09 | 2.75 ± 0.75*** | 3.48 ± 0.94 | — | — |
| Normalized MBF (ml min−1 g−1) | 0.79 ± 0.16** | 0.56 ± 0.13 | — | — | — | — |
| Total MBF (ml min−1) | 217 ± 61*** | 155 ± 28 | 1056 ± 272*** | 777 ± 223 | — | — |
| Coronary resistance (mmHg ml min−1 g−1) | 156 ± 32* | 122 ± 15 | 34 ± 11 | 25 ± 7 | — | — |
Rest, ADO and [11C]TMSX represent values at baseline, during adenosine and [11C]TMSX infusions, respectively. HR, heart rate; BPs, systolic blood pressure; BPd, diastolic blood pressure; MAP, mean arterial blood pressure; LV work, left ventricular myocardial work; MBF, myocardial blood flow. Adenosine increased HR as well as relative and total LV work significantly from rest to ADO in both groups, †P < 0.001. Percentage increase in these parameters was similar between the groups (∼75%). However, adenosine induced no changes in BPs, BPd and MAP, but ET had higher BPs, and lower HR and LV work in every measurement,
***
P < 0.001,
**
P < 0.01,
*
P < 0.05 compared to UT.