Table 2.

Protocol 2. Forearm and systemic haemodynamics during graded infusions of ATP and adenosine

Condition/dose	Forearm blood flow (ml min−1)	Mean arterial pressure (mmHg)	Forearm vascular conductance (ml min−1 (100 mmHg)−1)	Heart rate (beats min−1)
Baseline
Adenosine 1	21 ± 4	86 ± 3	25 ± 5	58 ± 5
ATP 1	23 ± 3	86 ± 3	27 ± 4	59 ± 5
Adenosine 2	23 ± 3	86 ± 3	27 ± 4	58 ± 5
ATP 2	22 ± 3	86 ± 3	26 ± 4	59 ± 4
Adenosine 3	23 ± 3	86 ± 3	28 ± 4	60 ± 5
ATP 3	24 ± 3	86 ± 3	28 ± 4	59 ± 5
Pre-phenylephrine
Adenosine 1	51 ± 8*	86 ± 3	61 ± 9*	60 ± 5
ATP 1	50 ± 9*	84 ± 3	61 ± 12*	58 ± 5
Adenosine 2	66 ± 9*	87 ± 2	77 ± 11*	59 ± 5
ATP 2	66 ± 9*	86 ± 3	78 ± 12*	59 ± 5
Adenosine 3	90 ± 12*	87 ± 3	105 ± 14*	60 ± 5
ATP 3	88 ± 13*	84 ± 3	106 ± 17*	59 ± 5
Phenylephrine
Adenosine 1	33 ± 6*†	88 ± 4	38 ± 7*†	60 ± 5
ATP 1	35 ± 7*†	87 ± 3	41 ± 9*†	59 ± 5
Adenosine 2	36 ± 6*†	90 ± 3*	41 ± 8*†	59 ± 5
ATP 2	53 ± 10*†	88 ± 4	62 ± 12*†	58 ± 5
Adenosine 3	43 ± 8*†	90 ± 4*	50 ± 10*†	60 ± 5
ATP 3	79 ± 11*‡	86 ± 3	94 ± 14*‡	59 ± 5

^*P< 0.05 vs baseline within condition;

^†P< 0.05 vs steady-state (Pre-vasoconstrictor; Phenylephrine) within condition;

^‡P< 0.05 vs adenosine during phenylephrine (α₁-agonist) infusion. 1 = Low dose condition; 2 = Moderate dose condition; 3 = High dose condition (see text for details). Forearm vascular conductance was calculated as (forearm blood flow/mean arterial pressure) × 100.