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EPSCs and input (Ri) and series (Rs) resistances were monitored by whole cell patch recordings. A, LTD was readily induced with vehicle (DMSO) present (61 ± 3% at 70–75 min). B, H-89 (20 μm in DMSO) blocks LTD (101 ± 10% at 70–75 min; mean ±s.e.m.; P < 0.002; t test). C, KT5720 (1 μm in DMSO) blocks LTD (102 ± 3% at 70–75 mi; P < 0.000004; t test). Open bars: 1 Hz/900 s stimulations; black bars: drug applications.
