Figure 3. Luminal Ba²⁺-induced changes of transepithelial voltage in distal colon from BK^+/+ and BK^−/− mice treated on a high K⁺ diet for 4 days.

A shows resting and luminal Ba²⁺-induced V_te changes in the continuous presence of luminal amiloride (100 μm). The upper line indicates V_te and the bandwidth of voltage deflections reflects the transepithelial resistance (R_te, see Methods) B, summary of calculated Ba²⁺-sensitive short-circuit current. WT, wild-type; KO, knock-out mice. *Statistically significant differences between animals of normal and high K⁺ diet.