Table I.

Definitions of replacement treatment regimens in haemophilia (Consensus Perspectives on Prophylactic Therapy for Haemophilia, London 20–21 September 2002, updated by the European paediatric Network for Haemophilia Management in 2006)

Regimen	Definition
Primary prophylaxis	Long-term continuous (at least 46 weeks/year)* treatment started
by age	before the age of 2 years and prior to any clinically evident joint bleeding
by first bleed	after no more than one joint bleed and before the age of 2 years
Secondary prophylaxis	Long-term continuous (at least 46 weeks/year)* treatment not fulfilling the criteria for primary prophylaxis
Short-term prophylaxis	Short-term regular treatment to prevent bleeding
On demand therapy	Treatment given when bleeding occurs

^*with the aim of treating 52 weeks/year up to adulthood