Table IV.

JOS²⁵ and ESPRIT²⁷ studies: comparison of patients and interventions

	JOS	ESPRIT
Enrolment	08/1996–04/2005	12/1996–06/1998
Enrolled patients, n. (prophylaxis/on-demand)	65 (32/33)	45 (23/22)
Evaluable patients*, n. (prophylaxis/on-demand)	57 (28/29)	40 (20/20)
Median age, years	1.6	4.0
Follow-up, months^	49	120
ELEGIBILITY CRITERIA
Age, months	< 30	< 84
FVIII activity	< 2	< 1
Joint bleeds	≤2	≥1°
Baseline orthopaedic and Pettersson scores	0	0
INTERVENTIONS
Prophylactic regimen, FVIII	25 IU/Kg e.o.d.	25 IU t.i.w. (target FVIII>1%)
On-demand treatment, FVIII	40 IU/Kg, 20 IU/Kg at 24 and 72 hrs and e.o.d. until recovery	≥ 25 IU/Kg, repeated until complete recovery

^*in the JOS, number of patients with radiological data for the assessment of the primary end-point; in the ESPRIT, number of patients following the treatment regimen assigned by randomisation.

^{^}median follow-up in the JOS, in which patients were evaluated at the age of 6 years old; planned follow-up in the ESPRIT.

^°at least one joint or muscle bleed in the 6 months before randomisation.