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Syntheses of 2FEE2 and 2FPE2. Reagents and conditions: (a) MOM*Cl, N,N-diisopropylethylamine, THF. (b) (1) sec-BuLi, THF, 78°C; (2) trimethylborate, 0°C to rt, >30 min; (3) aqueous NH4Cl. (c) Aqueous sodium perborate tetrahydrate, EtOAc. (d) 1-Bromo-2-fluoroethane (or 1-bromo-3-fluoropropane), K2CO3, Bu4NI, DMF, 100°C, 24 h. (e) 6N aqueous HCl, THF, 1 h. *MOM=methoxymethyl.
