FIGURE 1.

Lipin 1 deficiency does not affect PAP-1 activity in neonatal mice and leads to hepatic TG accumulation. A, the schematic depicts the pathways of TG synthesis from glycerol-3-phosphate (G3P) as well as the derivation of phospholipid. LPA, lysophosphatidic acid; PI, phosphatidylinositol; PE, phosphatidylethanolamine; PC, phosphatidylcholine; PS, phosphatidylserine. Asterisk, step that lipin proteins can catalyze. B, the graph illustrates mean hepatic PAP-1 or DG acyltransferase (DGAT) activity in P8 WT and fld littermate mice. C, the graphs depict mean hepatic TG (left) or phosphatidylcholine and phosphatidylethanolamine (right) levels in P8 WT and fld mice (n = 4) as quantified by ESI-MS. *, p < 0.01 versus littermate WT mice.