. 2009 Mar 13;284(11):6752–6762. doi: 10.1074/jbc.M805435200

TABLE 2.

Properties of Kir6.2 wild type, V59G, V59A, and ΔN10 channels formed with SUR1

Experiments in inside/outside patches –Mg²⁺; number of experiments are in parentheses.

Kir6.2	P_O^a	GBC (1 μm)	PIP₂ (10 μm) I_PIP2/I_control	Neomycin
Kir6.2	P_O^a	GBC (1 μm)	PIP₂ (10 μm) I_PIP2/I_control	30 μm	1000 μm
		% Inhibition	%	% Inhibition
Wild type	0.32 ± 0.10 (5)^b	71 ± 10 (4)	900 ± 390 (12)	57 ± 5 (9)	96 ± 2 (7)
	0.53 ± 0.02 (8)^c
V59G	0.83 ± 0.01 (8)^c	0 (10)	0 (4)	3 ± 2 (5)	16 ± 2 (5)
V59A	0.86 ± 0.01 (4)	15 ± 8 (7)	5 ± 3 (5)	17 ± 6 (6)	50 ± 11 (6)
ΔN10	0.61 ± 0.08 (4) (ΔN9)^b	9 ± 5 (12)	270 ± 40 (4)	17 ± 4 (10)	60 ± 8 (7)

P_O is the open probability of single channels in the absence of nucleotides.

Data from Reimann et al. (38) in Xenopus oocytes.

Data from Proks et al. (29) in Xenopus oocytes.