FIGURE 1.

Structure model of the TAFI-IIa-TM-EGF 456 complex. This complex was built based on the structure of bovine procarboxypeptidase A (CPA) in complex with chymotrypsinogen C (44) and the structure of IIa (secondary structures shown in green) in complex with TM-EGF 456 (red) (20). The TAFI model (yellow) and the catalytic triad of IIa were superimposed on CPA and the catalytic triad of chymotrypsinogen C complex, respectively. TM-EGF 456 structure retains its original orientation with respect to IIa (20). The positive residues on TAFI (side chains indicated in dark and light blue) may complement the negative residues on the C-loop of TM EGF 3, where the predicted position is indicated with the arrow.