TABLE 2.
Aminoglycoside substrate profile of APH(2″) enzymes
Note that three atypical aminoglycosides (streptomycin, spectinomycin, and hygromycin B) are not substrates for APH(2″)-Ib, -Ic, and -Id. Kinetic parameters for these substrates with APH(2″)-Ia enzyme are not reported. S, substrate; NS, not a substrate; NR, not reported. KanA, kanamycin A; Gen, gentamicin; Tob, tobramycin; Net, netilmicin; Dbk, dibekacin; Sis, sisomicin; Ise, isepamicin; Amk, amikacin; Arb, arbekacin; Neo, neomycin B; Par, paromomycin; Liv, lividomycin A; But, butirosin.
|
Enzyme
|
4,6-Disubstituted aminoglycosides
|
4,5-Disubstituted aminoglycosides
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kan | Gen | Tob | Net | Dbk | Sis | Ise | Amk | Arb | Neo | Par | Liv | But | |
| Ia | S | S | S | S | S | S | S | S | NR | S | S | S | S |
| Ib | S | S | S | S | S | S | S | S | S | NS | NS | NS | NS |
| Ic | S | S | S | S | S | S | NS | NS | NS | NS | NS | NS | NS |
| Id | S | S | S | S | S | S | S | S | S | NS | NS | NS | NS |