Gene expression in cells treated with Habc-EPM, Habc-Syn1a, and
Habc-1→2. a, gene expression fingerprint of SCp2 cells
treated with Habc-EPM, Habc-Syn1a, and Habc-1→2, normalized to expression
levels in untreated cells. Heat map displays expression for transcripts
regulated by >2-fold relative to untreated cells. b, real-time
quantitative PCR of MMP3, Fas, and matrix gla protein (Mgp)
transcripts, which are activated by Habc-EPM (EPM) and
Habc-1→2(1→2) relative to Habc-Syn1a
(Syn1a). c, real-time QPCR of aquaporin-3 (Aqp3)
and keratin-16 (Krt1–16) transcripts, which are inhibited by
Habc-EPM and Habc-1→2. All comparisons for b and c are
p < 0.05 for Habc-EPM and Habc-1→2 versus
Habc-Syn1a.