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Equilibrated molecular dynamics models and schematics of G5 PAMAM dendrimers with different numbers of ligands. Terminal amines (red), acetyl groups (orange), and ligands (blue) are depicted in the models. Corresponding schematic representations show the dendrimer in teal with terminal groups. PAMAM dendrimers are monodisperse, highly ordered, water soluble, polymeric nanoparticles (~4.5 nm diameter). Terminal amines can be used as coupling points to attach different ligands.
