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. 2009 Jan 16;8(3):1565–1576. doi: 10.1021/pr800904z

Table 2. Proteins with Increased Secretion into Pancreatic Cancer Serum Compared with Controls.

entry no. protein name cancer to control ratio entry no. protein name cancer to control ratio
1 RP26, ceramide kinase-like 19980.00 62 GANAB, alpha glucosidase II alpha subunit 5.13
2 ORP150 or HYOU1, oxygen regulated protein precursor 1012.33 63 PPIA, peptidylprolyl isomerase A 5.00
3 FLNA, filamin A, alpha 623.55 64 SHMT2, serine hydroxymethyltransferase 2 (mitochondrial) 5.00
4 UBE2L3, ubiquitin-conjugating enzyme E2L 3 isoform 1 332.22 65 DDT, D-dopachrome tautomerase 4.99
5 LMO7, LIM domain only 7 268.20 66 Eef1a1, eukaryotic translation elongation factor 1 alpha 1 4.49
6 FILIP, filamin A interacting protein 1 221.67 67 peroxiredoxin 6 4.47
7 STXBP2 or Unc18−2, syntaxin binding protein 2 215.77 68 catalase 4.31
8 CENPE, centromere protein E 204.00 69 S100P or MIG9, S100 calcium binding protein P 4.16
9 PTPRJ, protein tyrosine phosphatase, receptor type, J precursor 136.00 70 PREDICTED: similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) 4.07
10 ARHGEF15 or GEF 15, Rho guanine exchange factor 15 121.67 71 hypothetical protein LOC345651 4.00
11 PREDICTED: similar to Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma), eukaryotic translation elongation factor 1 gamma 120.94 72 GTP-binding protein PTD004 isoform 1 3.83
12 CLSTN1, calsyntenin 1 103.45 73 SMAP1L, stromal membrane-associated protein 1-like 3.65
13 DAK, dihydroxyacetone kinase 2 95.57 74 14−3−3 theta, tyrosine 3\tryptophan 5 -monooxygenase activation protein, theta polypeptide 3.65
14 ARPC2, Actin related protein 2\3 complex subunit 2 88.20 75 AXL, AXL receptor tyrosine kinase 3.63
15 MYH9, myosin, heavy polypeptide 9, nonmuscle 63.26 76 ACY1, aminoacylase 1 3.50
16 PDXK, pyridoxal kinase 62.54 77 carbonic anhydrase I 3.43
17 ON or SPARC, secreted protein, acidic, cysteine-rich (osteonectin) 56.72 78 PLCL2, phospholipase C-like 2 3.29
18 RKIP, prostatic binding protein 55.82 79 GPR126, G protein-coupled receptor 126 alpha 1, G protein-coupled receptor 126 beta 1, G protein-coupled receptor 126 alpha 2, G protein-coupled receptor 126 beta 2 3.20
19 AST, aspartate aminotransferase 1 55.00 80 3‘(2’), 5′-bisphosphate nucleotidase 1 3.19
20 cardiac muscle alpha Actin 1 proprotein 36.22 81 PSME1, proteasome activator subunit 1 3.15
21 PKP2, plakophilin 2 26.33 82 SERPINB1, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 3.00
22 CANT1, calcium activated nucleotidase 1 26.00 83 GSTO1, glutathione-S-transferase omega 1 3.00
23 S100A4, S100 calcium-binding protein A4 25.88 84 moesin 3.00
24 HNRPD or AUF1, heterogeneous nuclear ribonucleoprotein D 24.49 85 cathepsin C isoform a preproprotein 2.99
25 RCN1, reticulocalbin 1 precursor 23.62 86 ADP-ribosylation factor 1 2.98
26 ARHGDIA, Rho GDP dissociation inhibitor (GDI) alpha 23.30 87 TPI1, triosephosphate isomerase 1 2.96
27 B-CAM, basal cell adhesion molecule precursor 23.30 88 ACTN1, actinin, alpha 1 2.80
28 myosin regulatory light chain MRCL3, myosin regulatory light chain MRCL2 21.82 89 NUDT5, nudix-type motif 5 2.79
29 PLAP, placental alkaline phosphatase preproprotein 20.33 90 ERO1L, ERO1-like 2.78
30 LHPP, phospholysine phosphohistidine inorganic pyrophosphate phosphatase 19.92 91 uPA, urokinase plasminogen activator preproprotein 2.64
31 RRBP1, ribosome binding protein 1 19.67 92 P4HB, prolyl 4-hydroxylase, beta subunit precursor 2.63
32 CAPZA1, F-Actin capping protein alpha-1 subunit 19.42 93 hypothetical protein LOC57653 2.59
33 UBE2N, ubiquitin-conjugating enzyme E2N 18.30 94 MYEF2, myelin gene expression factor 2 2.56
34 EFHD2, EF hand domain family, member D2 16.82 95 RyR3, ryanodine receptor 3 2.56
35 Chd7, chromodomain helicase DNA binding protein 7 16.75 96 ras homologue gene family, member A 2.51
36 GGH, gamma-glutamyl hydrolase precursor 16.03 97 ENO1, enolase 1 2.50
37 CAPZB, F-Actin capping protein beta subunit 15.27 98 DENN\MADD domain containing 2C 2.50
38 intercellular adhesion molecule 1 precursor 14.00 99 EPS8L1, epidermal growth factor receptor pathway substrate 8-like protein 1 isoform a 2.50
39 CLIC1, chloride intracellular channel 1 13.84 100 proteasome alpha 5 subunit 2.48
40 DJ-1 protein 13.19 101 BAIAP2, BAI1-associated protein 2 2.45
41 TPP1, tripeptidyl-peptidase I preproprotein 12.51 102 cathepsin D preproprotein 2.44
42 SDCBP2, syndecan binding protein 2 12.48 103 Maspin (SERPINB5), serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 2.42
43 major histocompatibility complex, class I, B, PREDICTED: similar to HLA class I histocompatibility antigen, B-18 alpha chain precursor (MHC class I antigen B*18) 12.31 104 PGLS, 6-phosphogluconolactonase 2.35
44 Sumo 2 or Sumo 3, PREDICTED: similar to SMT3 suppressor of mif two 3 homologue 2, small ubiquitin-like modifier protein 3 12.13 105 14−3−3zeta, tyrosine 3\tryptophan 5 -monooxygenase activation protein, zeta polypeptide, tyrosine 3\tryptophan 5 -monooxygenase activation protein, zeta polypeptide 2.25
45 BLVRB, biliverdin reductase B (flavin reductase (NADPH)) 10.50 106 Chaperonin 2.21
46 zinc finger protein 704 10.00 107 heme binding protein 2 2.16
47 S100A16, S100 calcium binding protein A16 9.10 108 SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3 2.13
48 SEMA7A, semaphorin 7A 8.49 109 keratin 8 2.02
49 CHMP2B, chromatin modifying protein 2B 8.49 110 vinculin isoform VCL, vinculin isoform meta-VCL 2.00
50 NSD1, nuclear receptor binding SET domain protein 1 7.67 111 collagen, type VI, alpha 1 precursor 1.96
51 myoglobin 7.15 112 podocalyxin-like precursor 1.88
52 STIP1, stress-induced-phosphoprotein 1 (Hsp70\Hsp90-organizing protein) 7.00 113 TCN1, transcobalamin I precursor 1.85
53 IFI30 or IP-30, interferon, gamma-inducible protein 30 preproprotein 7.00 114 BST2, bone marrow stromal cell antigen 2 1.81
54 NME1-NME2 protein 6.74 115 keratin 18 1.76
55 ephrin receptor EphA2 6.68 116 HSPG2, heparan sulfate proteoglycan 2 1.73
56 RNPEP, arginyl aminopeptidase (aminopeptidase B) 6.50 117 Ezrin, villin 2 1.69
57 DENN\MADD domain containing 2A 6.13 118 cytosolic malate dehydrogenase 1.65
58 TAL1 or TALDO1, transaldolase 1 6.00 119 MMP-7, matrix metalloproteinase 7 preproprotein 1.61
59 PVRL1 or CD111, poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin) 5.64 120 TAGLN2, transgelin 2 1.57
60 APLP2, amyloid beta (A4) precursor-like protein 2 5.50 121 cystatin M precursor 1.52
61 ARMET, arginine-rich, mutated in early stage tumors 5.18