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(a) PC12 cells. (b) PC12 cells treated with neuregulin. (c) PC12 cells transfected with ErbB4. (d) PC12 + ErbB4 cells treated with neuregulin showing neurite outgrowth. (e) PC12 + ErbB4 cells treated with neuregulin in the presence of the silylated precursor to 52. (f) PC12 + ErbB4 cells treated with neuregulin in the presence of 52. Pyridine 52 was found to be a potent inhibitor of this cellular activity (EC50 = 0.30 µM). See the Supporting Information for details.
