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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Free Radic Biol Med. 2008 Jun 28;45(6):905–912. doi: 10.1016/j.freeradbiomed.2008.06.020

Figure 3. An inhibitor of NAD(H) oxidase reduces superoxide radicals and protein nitrosylation in the retinas of rd1 mice.

Figure 3

There was minimal fluorescence in the retinas of P30 wild type mice after systemic Injection of hydroethidine (A–C), but the retinas of P30 rd1 mice showed prominent fluorescence in the remaining outer retina (D–F). Rd1 mice treated with intraperitoneal injections of PBS between P15 and P30 also showed strong fluorescence in the retina (G–I), but rd1 mice treated with intraperitoneal injections of apocynin between P15 and P30 showed only mild fluorescence (J–L). Rd1 mice treated with subcutaneous injections of PBS between P15 and P30 showed strong staining for nitrotyrosine in cells of the inner and remaining outer nuclear layer (M–O, arrow), but rd1 mice treated with apocynin showed mild staining (P–R). Scale bars = 50 µm