Table 4.
Methotrexate attenuated CIA in gp130F759 mice (male, histopathological analysis)
| Day 42 | Vehicle | MTX | |
| Grade | 24* | 22* | |
| Proliferation of the synovial lining cells | 0 | 7 | 16 |
| 1 | 0 | 0 | |
| 2 | 12 | 3 | |
| 3 | 5 | 3 | |
| 4 | 0 | 0 | |
| Destruction of the articular cartilage/bone | 0 | 6 | 16 |
| 1 | 0 | 0 | |
| 2 | 3 | 2 | |
| 3 | 15 | 4 | |
| 4 | 0 | 0 | |
| Inflammatory cell infiltration, rich in neutrophils | 0 | 5 | 15 |
| 1 | 0 | 0 | |
| 2 | 4 | 1 | |
| 3 | 11 | 6 | |
| 4 | 4 | 0 | |
All data refer to the number of limbs with the finding in the group.
*Total number of limbs in the group
Grade of change: 0, negative; 1, very slight; 2, slight; 3, moderate; 4, severe.