Figure 1.
Effects of ISO on cardiac function in vivo. A, Representative echocardiographic measurements in WT and S2808A animals before and after ISO. B, ISO caused significant increases in heart rate in both WT and S2808A mice. There were no differences in the response between the 2 groups. C, ISO caused significant increases in ejection fraction (EF) in WT and S2808A mice. There were no differences in ISO effects between groups. D, ISO caused significant increases in fractional shortening in WT and S2808A mice, with no differences between the response in the 2 groups.