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. Author manuscript; available in PMC: 2009 Mar 6.

Published in final edited form as: Circ Res. 2008 Apr 3;102(8):e65–e72. doi: 10.1161/CIRCRESAHA.108.174722

Table 2.

LV Performance

	Wild Type (n=5)		RYR-S2808A (n=6)		Percentage Change
	Baseline	ISO	Baseline	ISO	WT	RYR-2808A
LV Dev P (mm Hg)	79±10	147±20^*	74±4	151±16^*	87±12	102±15
LVEDP (mm Hg)	9±0.7	10.5±0.9	10±0.5	10±0.5
+dP/dt (mm Hg/sec)	3917±584	7799±647^*	3444±87	8259±664^*	104±21	138±14
−dP/dt (mm Hg/sec)	−2569±385	−5052±691^*	−2225±87	−5180±499^*	102±19	132±20
Perfusion pressure (mm Hg)	80±0.4	80±0.4	80±3	80±4
Heart rate (bpm)	465±14	460±13	466±12	469±12

Data are presented as means±SEM. Concentration of ISO was 10 nmol/L. LV Dev P indicates LV developed pressure; LVEDP, LV end-diastolic pressure.

^*

P<0.01 vs group baseline.