Table 4.
Association between SEPS1 polymorphism and tumor location, staging and Lauren's classification
| Variables(n) | genotype | G/G vs. G/A+A/A | |||
|---|---|---|---|---|---|
| G/G | G/A | A/A | OR(95%CI) | P | |
| Patients without GC(306) | 283 | 22 | 1 | Reference | |
| Tumor location | |||||
| Cardia(5) | 5 | 0 | 0 | 1.93(0.40–9.22) | 0.411 |
| Non-cardia(263) | 232 | 30 | 1 | 2.81(0.69–11.48) | 0.15 |
| Upper third(16) | 14 | 2 | 0 | ND | |
| Middle third(134) | 115 | 19 | 0 | 2.01(1.03–3.92) | 0.041 |
| Lower third(113) | 103 | 9 | 1 | 1.18(0.52–2.64) | 0.696 |
| Staging | |||||
| Early(138) | 121 | 17 | 0 | 1.74(0.88–3.47) | 0.112 |
| Advanced(130) | 117 | 12 | 1 | 1.52(0.74–3.12) | 0.253 |
| Lauren's classification | |||||
| Intestinal type(151) | 132 | 19 | 0 | 1.99(1.01–3.93) | 0.047 |
| Diffuse type(110) | 100 | 9 | 1 | 1.19(0.54–2.63) | 0.659 |
| Mixed(7) | 5 | 2 | 0 | 6.82(1.07–43.65) | 0.043 |
NOTE: All data are adjusted for sex, age, and H. pyloriinfection status. ND: not determined, GC: gastric cancer, CI: confident interval