Table 2.
Weight, BMI, and total body fat (by DEXA) measured during on- and off-r-metHuLeptin EHC
|
2005 |
2006
|
2007
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Weight | BMI | Total fat | Weight | BMI | Total fat | Weight | BMI | Total fat | |
| Patient A | |||||||||
| On leptin | 64.7 | 23.5 | 10.4 | 66.6 | 24.3 | 13.2 | 63.5 | 23.0 | 7.0 |
| Off leptin | 65.3 | 23.7 | 72.8 | 26.4 | 73.5 | 26.7 | |||
| Patient B | |||||||||
| On leptin | 63.2 | 25.1 | 26.0 | 64.8 | 27.5 | 32.2 | 61.7 | 26.4 | 36.4 |
| Off leptin | 69.0 | 26.9 | 68.9 | 29.3 | 68.0 | 29.0 | |||
| Patient C | |||||||||
| On leptin | 72.8 | 29.8 | 31.8 | 77.3 | 31.6 | 36.6 | 75.7 | 32.3 | 45.0 |
| Off leptin | 77.5 | 31.7 | 81.4 | 33.3 | 84.8 | 36.2 | |||
BMI, body mass index; DEXA, dual-energy X-ray absorptiometry; r-metHuLeptin, recombinant methionyl human leptin; EHC, euglycemic hyperinsulinemic clamps.