Table 1.

Targeted genomic deletion of HO2 attenuates the electrical response to EFS

	Wild type (n = 12)	HO2Δ/Δ (n = 8)
Hyperpolarization, mV	7.6  ±  0.6	2.6  ± 1.02∗
Reduction in amplitude of first slow wave, %	47  ±  3.3	15  ± 3.8∗
Reduction in amplitude of second slow wave, %	22  ±  4.6	1.6  ± 1.6∗
Reduction in amplitude of third slow wave, %	9.7  ±  2	0  ± 0∗

Targeted genomic deletion of HO2 results in attenuation of electrical response to EFS in jejunal smooth muscle preparations. The initial hyperpolarization or IJP in response to EFS is only 2.6 mV in HO2^Δ/Δ-derived specimens compared to 7.6 mV in wild-type samples. In addition, the reduction in the amplitude of the first three electrical slow waves after EFS is significantly attenuated in the HO2^Δ/Δ-derived specimens compared to wild-type samples. The number of independent measurements is indicated by (n), and statistical significance is indicated (∗, P < 0.05).