. Author manuscript; available in PMC: 2009 Dec 1.

Published in final edited form as: Int J Cancer. 2008 Dec 1;123(11):2636–2643. doi: 10.1002/ijc.23838

Table 3.

Multivariate Cox Proportional Hazards analysis

Variable	N	Progression		Metastasis		PCa-specific Death
Variable	N	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Gleason Score
<7	121	1.00	<0.0001^*	1.00	0.019^*	1.00	0.022^*
≥7	131	2.40 (1.60-3.57)	<0.0001^*	2.24 (1.14-4.40)	0.019^*	2.96 (1.17-7.49)	0.022^*
Organ Confined
Yes	60	1.00	0.192	1.00	0.156
No	192	1.73 (0.76-3.97)	0.192	0.34 (0.07-1.51)	0.156
Focal Extra-Prostatic Extension
No	79	1.00	0.409	1.00	0.238
Yes	173	0.79 (0.44-1.39)	0.409	1.88 (0.67-5.42)	0.238
Non-Focal Extra-Prostatic Extension
No	115	1.00	0.539	1.00	0.063	1.00	0.589
Yes	137	1.16 (0.72-1.86)	0.539	2.37 (0.95-5.87)	0.063	1.28 (0.53-3.10)	0.589
Surgical Margin
Negative	175	1.00	0.001^*	1.00	0.501	1.00	0.057
Positive	77	1.91 (1.31-2.81)	0.001^*	1.21 (0.68-2.16)	0.501	1.98 (0.98-4.02)	0.057
Seminal Vesicle
Negative	217	1.00	0.849	1.00	0.056	1.00	0.994
Positive	35	1.05 (0.65-1.70)	0.849	1.87 (0.98-3.54)	0.056	1.00 (0.44-2.25)	0.994
Lymph Node
Negative	230	1.00	0.078	1.00	0.061	1.00	0.003^*
Positive	22	1.62 (0.94-2.78)	0.078	1.96 (0.97-3.97)	0.061	3.57 (1.54-8.30)	0.003^*
Her-2/neu
Negative	85	1.00	0.001^*	1.00	0.001^*	1.00	0.012^*
Positive	167	2.06 (1.36-3.10)	0.001^*	3.57 (1.68-7.59)	0.001^*	3.39 (1.30-8.83)	0.012^*
%DNA Index
≤7	104	1.00	<0.0001^*	1.00	0.014^*	1.00	0.039^*
>7	148	2.23 (1.49-3.32)	<0.0001^*	2.29 (1.18-4.42)	0.014^*	2.60 (1.04-6.45)	0.039^*

Significant