Figure 2. Expression of mutant HTT in HD monkey peripheral tissues and brains.
a-d, mEM48 immunoblot of peripheral and brain tissues reveals high-molecular-mass oligomeric HTT (arrow) and soluble HTT products. The blot was also probed with an antibody to γ-tubulin as an internal control. Shown are immunoblots of peripheral tissues collected from monkey rHD-4 (a) and rHD-5 (b), and samples from different brain regions of monkey rHD-4 (c) and rHD-5 (d), with antibody to mEM48 (top panel) and γ-tubulin (bottom panel). WT, wild-type non-transgenic monkey.