Table 1.
Summary of transgenic HD monkeys
| Movement dysfunction |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| rHD | Sex | CAG repeats | HTT copy number | Expression of mutant HTT/GFP | Body weight ratio | Onset/ frequency | Dystonia | Chorea | Swallowing difficulty | Respiratory difficulty |
| F, female; M, male; ND, not determined. | ||||||||||
| 1 | M | 29 | 1 | +/+ | 2.85* | − | − | − | − | − |
| 2 | M | 83 | 1 | +/+ | 2.16* | 1 week/ sporadic | + | + | − | + |
| 3 | F | 84 | 2 | +/+ | 1.11† | 2-3 days/ persistent | ++++ | ++++ | ++++ | ++ |
| 4 | F | 27, 65 | 2 | +/+ | ND | At birth/ persistent | ++ | ++ | ND | ++++ |
| 5 | F | 88 | 4 | +/+ | ND | At birth/ ND | ND | ND | ND | ++++ |
*
The ratio of body weight at 24 weeks after birth to birth weight.
†
The ratio of body weight at 28 days after birth to birth weight.