Table 3.
Inhibition of α-thrombin induced cleavage of S2238 by FM compounds
Peptide | Ki (µm)† | Inhibition type |
---|---|---|
FM19 | 4.4 ± 2.4 | C* |
FM29 | 5.1 ± 2.6 | C |
FM33 | 8.2 ± 3.3 | C |
FM36 | 4.1 ± 1.3 | C |
FM39 | 7.5 ± 3.2 | C |
C, competitive inhibition.
In 10 mm Tris-HCl, 150 mm NaCl at pH 8.0 and 25 °C.
With a ± 95% confidence interval.