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Histograms of odds ratios for developing anti-CCP-positive (A) and anti-CCP-negative (B) rheumatoid arthritis (RA) for different combinations of absence or presence of R620 W PTPN22, single or double HLA-DRB1 shared epitope (SE) alleles, and smoking (see text). CCP, cyclic citrullinated peptide. Reproduced from Kallberg et al Am J Hum Genet 2007;80:867–75) with permission.
