Figure 2.

The lineage choice of endogenous oligodendrocyte progenitors can be manipulated by systemic administration of valproic acid. Postnatal day 2 rats were injected with PBS or VPA twice per day for 7 d. Oligodendrocytes, astrocytes, or neurons were identified in the P9 corpus callosum (A, B) and cortex (C), using antibodies against CC1 (A; red), GFAP (B; red; white arrows), or NeuN (C; red). DAPI (blue) was used as a nuclear stain. Scale bar, 20 μm.