Table 2.

SNPs meeting Bonferroni threshold for significance in the CATHGEN sample set for 19 SNPs

SNP	Young affected (n = 599)		Old affected (n = 207)		All affected (n = 806)		MI (n = 425)		GC Proband (n = 718)
	P-value*	OR	P-value*	OR	P-value*	OR	P-value*	OR	P-value*	OR
Adjusted for race and sex
RS12528857	0.02	0.70	0.002	0.56	0.004	0.67	0.02	0.69	0.85	1.02
RS1051931	0.01	1.50	0.0001	2.10	0.002	1.61	0.002	1.68	0.08	1.30
RS2216465	0.05	0.79	0.001	0.59	0.008	0.74	0.01	0.72	0.04	0.79
RS6899519	0.03	0.76	0.0001	0.51	0.002	0.68	0.006	0.69	0.15	0.86
RS1362931	0.05	1.37	0.002	1.82	0.02	1.45	0.01	1.52	0.21	1.21
RS1805017	0.01	0.73	0.0001	0.50	0.0007	0.66	0.0008	0.63	0.00	0.70
RS6929105	0.002	1.55	0.0001	2.10	0.0004	1.62	0.0009	1.66	0.07	1.23
RS3799862	0.00	1.52	0.0002	1.97	0.0006	1.58	0.0008	1.66	0.02	1.36
RS9381475	0.16	0.81	0.0006	0.51	0.02	0.73	0.03	0.71	0.34	0.88
Adjusted for race, sex and cardiovascular risk factors
RS12528857	0.10	0.77	0.01	0.59	0.02	0.71	0.09	0.75	0.63	1.07
RS1051931	0.10	1.33	0.003	1.85	0.02	1.47	0.02	1.52	0.22	1.23
RS2216465	0.08	0.79	0.004	0.61	0.01	0.73	0.01	0.71	0.06	0.79
RS6899519	0.09	0.79	0.0003	0.50	0.007	0.70	0.01	0.69	0.21	0.87
RS1362931	0.44	1.15	0.02	1.62	0.16	1.25	0.13	1.33	0.28	1.20
RS1805017	0.04	0.75	0.0002	0.49	0.003	0.67	0.002	0.62	0.01	0.71
RS6929105	0.11	1.29	0.0009	1.92	0.02	1.40	0.03	1.43	0.09	1.23
RS3799862	0.09	1.30	0.002	1.81	0.02	1.40	0.02	1.47	0.06	1.33
RS9381475	0.35	0.86	0.0007	0.48	0.05	0.74	0.04	0.70	0.62	0.93

Odds ratios (OR) and P-values were obtained using standard logistic regression and are reported for all CATHGEN case samples, as well as GENECARD (GC) probands relative to the CATHGEN old normal controls (ON). Bolded numbers indicate SNPs meeting Bonferroni significance. YA, young affected; OA, old affected; AA, all affected; MI, CATHGEN samples with MI.