Table 4.
Clinical characteristics of CATHGEN and GENECARD proband participants
| Category | Characteristic | CATHGEN | GENECARD | |||||
|---|---|---|---|---|---|---|---|---|
| Young affected (n = 599) | Old affected (n = 207) | Unaffected controls (n = 266) | Probands (n = 757) | Genecard 1 (n = 1127) | Genecard 2 (n = 1757) | Total Genecard set (n = 2862) | ||
| Mean age of onset (SD) | 46.3b | 65.7 | NA | 43.6a | NA | NA | NA | |
| Race | Caucasian (%) | 70.51b | 89.86a | 74.69 | 85.49a | 92.9 | 88.4 | 90.2 |
| African American (%) | 22.37b | 8.7a | 20 | 7.65a | 2.7 | 4.6 | 3.8 | |
| American Indian (%) | 5.76b | 1.45a | 4.08 | 2.77a | 3.8 | 4.6 | 4.3 | |
| Other (unknown) (%) | 1.36b | 0a | 1.22 | 4.09a | 0.6 | 2.4 | 1.7 | |
| Gender | Male (%) | 78.63a | 72.46a | 39.47 | 68.73a | 66.0 | 61.0 | 62.8 |
| Family history of CAD (%) | 54.09a,b | 42.03a | 22.18 | 100a | 89.2 | 72.5 | 78.9 | |
| Body mass index, kg/m2 (SD) | 30.8 (6.5)a,b | 28.4 (6.5) | 29 (7.7) | 31.6 (7.6) | 29.5 (5.7) | 30.0 (7.6) | 29.8 (7.0) | |
| Ever smoked (%) | 68.61a,b | 52.17a | 39.10 | 26.65a | 74.7 | 71.6 | 72.8 | |
| History of diabetes (%) | 33.06a | 31.4a | 17.29 | 24.9a | 20.1 | 19.6 | 19.8 | |
| History of hypertension (%) | 69.62b | 77.29a | 63.53 | 63.3a | 54.2 | 53.7 | 53.9 | |
| History of coronary artery bypass graft | 36.23%b | 51.21% | NA | 48.88%a | 38.9% | 32.9% | 35.4% | |
| History of myocardial infarction | 313b | 81 | NA | 480a | 674 | 1023 | 1683 | |
| Mean systolic blood pressure, mmHg (SD) | 139.7 (23.9)a,b | 150.1 (26.1) | 149.5 (23.7) | 126.7 (19.3)a | 146.1 (24.7) | 137.9 (23.0) | 138.2 (23.1) | |
| Mean diastolic blood pressure, mmHg (SD) | 78.1 (14.3) | 77.2 (12.7) | 76.6 (13.4) | 76.1 (12.1) | 81.3 (11.0) | 81.4 (12.3) | 81.4 (12.2) | |
| Total cholesterol, mg/dl (SD) | 194.7 (62.8)b | 175.6 (39.9)a | 193.4 (49.9) | 219.3 (56.4)a | 188.9 (116.9) | 208.2 (81.4) | 199.1 (100.7) | |
| Low-density lipoprotein, mg/dl (SD) | 111.9 (42.7) | 104 (33.3) | 108.7 (36.4) | 142.1 (73.9)a | 87.2 (97.4) | 113.4 (76.7) | 101.2 (88.5) | |
| High-density lipoprotein, mg/dl (SD) | 40.2 (12)aa,b | 44.2 (14.5)a | 52 (18) | 43.5 (50.9) | 25.2 (35.6) | 37.2 (37.0) | 31.6 (37.0) | |
| Triglycerides, mg/dl (SD) | 227.2 (268.8)a,b | 157.4 (88.3) | 159.6 (137.6) | 240.1 (310.3) | 170.5 (194.5) | 215.7 (278.6) | 193.6 (241.5) | |
Clinical characteristics are listed for each subgroup of the CATHGEN sample set (young affected, old affected and unaffected controls) as well as for the GENECARD probands and the entire GENECARD family cohort.
a
Significant difference (P < 0.05) between GENECARD probands and Cathgen young affected cases or CATHGEN cases and controls.
b
Significant difference (P < 0.05) between CATHGEN YA and OA samples.