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Asbestos-treated mice showed marked pulmonary fibrosis 14 days after exposure to crocidolite asbestos. Treatment with 10 mg/kg/day imatinib mesylate diminished asbestos-induced airway thickening. Asbestos-treated mice with daily intraperitioneal injections of (a) vector or (b) 10 mg/kg/day imatinib mesylate. (c) Histology score as described in Materials and Methods, indicating the degree of pulmonary fibrosis (n = 2 for asbestos with vector; n = 3 for asbestos with imatinib mesylate).
