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. Author manuscript; available in PMC: 2009 Mar 9.
Published in final edited form as: J Nucl Med. 2008 Dec 17;50(1):108–115. doi: 10.2967/jnumed.108.056226

FIGURE 1.

FIGURE 1

(A) Time-activity curve after injection of 11C-dLop in the temporal cortex fitted with one-tissue (solid) and two-tissue (dash) compartment models at baseline (●) and after P-gp blockade (○) (DCPQ 8 mg/kg, i.v.). Only the one-tissue compartment model was used at baseline because of low brain uptake. All tissue curves were corrected for vascular volume assuming that blood constitutes 5% of brain volume. (B) Plasma parent radiotracer time-activity curve at baseline (●) and after P-gp blockade (○) in a single monkey