TABLE 2.

Cerebral blood flow and extraction fraction at baseline and after P-gp blockade^*

	CBF (mL · cm−3 · min−1)		Extraction fraction
Region	Baseline	Blocked	Baseline (n=3)	Blocked (n=5)
Frontal cortex	0.37 ± 0.09	0.43 ± 0.17	0.09 ± 0.04	0.43 ± 0.10
Anterior cingulate	0.48 ± 0.12	0.54 ± 0.20	0.06 ± 0.03	0.42 ± 0.12
Temporal cortex	0.46 ± 0.07	0.58 ± 0.18	0.12 ± 0.03	0.40 ± 0.09
Pariatal cortex	0.32 ± 0.02	0.37 ± 0.15	0.12 ± 0.06	0.57 ± 0.13
Hippocampus	0.43 ± 0.04	0.51 ± 0.15	0.12 ± 0.04	0.42 ± 0.13
Occipital cortex	0.31 ± 0.04	0.38 ± 0.19	0.12 ± 0.06	0.58 ± 0.10
Putamen	0.64 ± 0.07	0.95 ± 0.15	0.06 ± 0.02	0.31 ± 0.10
Cerebellum	0.61 ± 0.22	0.67 ± 0.12	0.05 ± 0.02	0.42 ± 0.13
Mean	0.45	0.56	0.09	0.44

^*P-gp was blocked by DCPQ 8 mg/kg (n=4) or 16 mg/kg (n=1), i.v., 30 min prior to injection of ¹¹C-dLop Cerebral blood flow (CBF) is reported as mean ± SD from 3 monkeys

Extraction fraction was calculated using the mean CBF's to the left and averaged across monkeys