Figure 3.
T-bet and Egr-2 were detected in the nuclear extracts of PI-Treg cells and associated with the induction of p27kip. Cytosolic and nuclear proteins were extracted from CD4 T cells from naive and tolerant mice before and after stimulation with Ac1-9[4Y] for 2 h. Western blots were stained with antisera specific for (A) Egr-2, p27kip and (B) T-bet, respectively, as indicated. The cytosolic and nuclear extracts in (B) are indicated as C and N. The results shown are representative of three separate experiments.