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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Jun 13;1793(1):171–180. doi: 10.1016/j.bbamcr.2008.06.003

Fig. 1.

Fig. 1

Muscle pathology from Cox10 KO (muscle conditional) mice closely resembles human clinical findings. Triceps surae muscle from 3-month-old mice was snap frozen in isopentane cooled in liquid nitrogen. Serial cross sections of 8 μm thickness were stained for cytochrome c oxidase activity, combined cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) activity, succinate dehydrogenase activity, Gomori Trichrome stain and immunostained with Alexa conjugated COXI monoclonal antibody to show the a COX deficiency and mitochondrial proliferation in muscles of the Cox10 knockout mice. The non-synchronous Cre deletion of the gene reproduces the mosaic pattern observed in patients with mtDNA mutations.