Table 5 Conventional karyotype in three prenatal cases with de novo complex chromosome rearrangements.

Patient	Conventional and painting karyotype	Ecographic findings	Follow‐up
57	der(3)t(3;15)(p13;q13)t(3;21)(p11;q11),der(4)(p15)ins(10;4)(q11;p15),t(7;11)(p15;p13), der(9)t(9;10)(p13;q11), der(10)t(3;10)(q22;q11) ins(10;4)(q11;p15),der(15)t(3;15)(p13;q13),der(21)t(9;21)(p13;q11)10 G‐banding+SKY; balanced	Normal	—
58	t(5;6;8)(5pter→5q35::6q21→6q27::8q22→8qter; 6pter→6q21::5q35→5qter; 8pter→8q22::6q27→6qter)4 Q‐banding+ painting; balanced	Normal	—
59	ish inv(11)(p11.2q13), ins(16;11)(q12;q13q14) Q‐banding; balanced	Normal	At birth. microtia, low‐set abnormal ears, facial dysmorphisms